Jin lab members indicated with bold

Equal contributions indicated with asterisk*

Corresponding authors indicated with hash#

Cell ⎜June 2024 BioRxiv⎜September 2023

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

Xinhe Zheng, Boli Wu, Yuejia Liu, Sean K. Simmons, Kwanho Kim, Grace S. Clarke, Abdullah Ashiq, Joshua Park, Jiwen Li, Zhilin Wang, Liqi Tong, Qizhao Wang, Keerthi T. Rajamani, Rodrigo Muñoz-Castañeda, Shang Mu, Tianbo Qi, Yunxiao Zhang, Zi Chao Ngiam, Naoto Ohte, Carina Hanashima, Zhuhao Wu, Xiangmin Xu, Joshua Z. Levin, Xin Jin#

BioRxiv⎜February 2024

Neuronal-class specific molecular cues drive differential myelination in the neocortex

Vahbiz Jokhi, Nuria Domínguez-Iturza, Kwanho Kim, Ashwin S. Shetty, Wen Yuan, Daniela Di Bella, Catherine Abbate, Paul Oyler-Castrillo, Xin Jin, Sean Simmons, Joshua Z. Levin, Juliana R. Brown & Paola Arlotta

Human Molecular Genetics⎜June 2023

Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity

Martina Pigoni, Ana Uzquiano, Bruna Paulsen, Amanda J Kedaigle, Sung Min Yang, Panagiotis Symvoulidis, Xian Adiconis, Silvia Velasco, Rafaela Sartore, Kwanho Kim, Ashley Tucewicz, Sarah Yoshimi Tropp, Kalliopi Tsafou, Xin Jin, Lindy Barrett, Fei Chen, Edward S Boyden, Aviv Regev, Joshua Z Levin & Paola Arlotta

Cell⎜September 2022

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex

Ana Uzquiano, Amanda J Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z. Levin & Paola Arlotta

Nature ⎜July 2022

Neurotensin orchestrates valence assignment in the amygdala

Hao Li, Praneeth Namburi, Jacob M. Olson, Matilde Borio, Mackenzie E. Lemieux, Anna Beyeler, Gwendolyn G. Calhoon, Natsuko Hitora-Imamura, Austin A. Coley, Avraham Libster, Aneesh Bal, Xin Jin, Huan Wang, Caroline Jia, Sourav R. Choudhury, Xi Shi, Ada C. Felix-Ortiz, Verónica de la Fuente, Vanessa P. Barth, Hunter O. King, Ehsan M. Izadmehr, Jasmin S. Revanna, Kanha Batra, Kyle B. Fischer, Laurel R. Keyes, Nancy Padilla-Coreano, Cody A. Siciliano, Kenneth M. McCullough, Romy Wichmann, Kerry J. Ressler, Ila R. Fiete, Feng Zhang, Yulong Li & Kay M. Tye

Nature Biotechnology⎜August 2021

Compact RNA editors with small Cas13 proteins

Soumya Kannan*, Han Altae-Tran*, Xin Jin, Victoria Madigan, Rachel Oshiro, Kira Makarova, Eugene V. Koonin & Feng Zhang

Science⎜August 2021

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

Michael Segel, Blake Lash, Jingwei Song, Alim Ladha, Catherine C. Liu, Xin Jin, Sergei L. Mekhedov, Rhiannon K. Macrae, Eugene V. Koonin & Feng Zhang

Nature⎜March 2021

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

Sekyu Choi, Bing Zhang, Sai Ma, Meryem Gonzalez-Celeiro, Daniel Stein, Xin Jin, Seung Tea Kim, Yuan-Lin Kang, Antoine Besnard, Amelie Rezza, Laura Grisanti, Jason D. Buenrostro, Michael Rendl, Matthias Nahrendorf, Amar Sahay & Ya-Chieh Hsu

PNAS⎜March 2021

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Min Qiu, Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui, Zhongfeng Ye, Yamin Li, Feng Zhang & Qiaobing Xu

Nature Biomedical Engineering⎜December 2020

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

Maturada Patchsung, Krittapas Jantarug, Archiraya Pattama, Kanokpol Aphicho, Surased Suraritdechachai, Piyachat Meesawat, Khomkrit Sappakhaw, Nattawat Leelahakorn, Theerawat Ruenkam, Thanakrit Wongsatit, Niracha Athipanyasilp, Bhumrapee Eiamthong, Benya Lakkanasirorat, Thitima Phoodokmai, Nootaree Niljianskul, Danaya Pakotiprapha, Sittinan Chanarat, Aimorn Homchan, Ruchanok Tinikul, Philaiwarong Kamutira, Kochakorn Phiwkaow, Sahachat Soithongcharoen, Chadaporn Kantiwiriyawanitch, Vinutsada Pongsupasa, Duangthip Trisrivirat, Juthamas Jaroensuk, Thanyaporn Wongnate, Somchart Maenpuen, Pimchai Chaiyen, Sirichai Kamnerdnakta, Jirawat Swangsri, Suebwong Chuthapisith, Yongyut Sirivatanauksorn, Chutikarn Chaimayo, Ruengpung Sutthent, Wannee Kantakamalakul, Julia Joung, Alim Ladha, Xin Jin, Jonathan Gootenberg, Omar Abudayyeh, Feng Zhang, Navin Horthongkham & Chayasith Uttamapinant

Science⎜November 2020

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes

Xin Jin# , Sean K Simmons, Amy Guo, Ashwin S Shetty, Michelle Ko, Lan Nguyen, Vahbiz Jokhi, Elise Robinson, Paul Oyler, Nathan Curry, Giulio Deangeli, Simona Lodato, Joshua Z Levin, Aviv Regev#, Feng Zhang# & Paola Arlotta#

Nature Human Behavior⎜September 2020

Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing

William Allen*, Han Altae-Tran*, James Briggs*, Xin Jin*, Glen McGee*, Andy Shi*, Rumya Raghavan, Mireille Kamariza, Nicole Nova, Albert Pereta, Chris Danford, Amine Kamel, Patrik Gothe, Evrhet Milam, Jean Aurambault, Thorben Primke, Weijie Li, Josh Inkenbrandt, Tuan Huynh, Evan Chen, Christina Lee, Michael Croatto, Helen Bentley, Wendy Lu, Robert Murray, Mark Travassos, Brent Coull, John Openshaw, Casey Greene, Ophir Shalem, Gary King, Ryan Probasco, David Cheng, Ben Silbermann, Feng Zhang & Xihong Lin